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She was married to Thaddaeus Scheel, with whom she worked on The Spitfire Grill (1996), from 1996 to 2012. She returned to movie making in the mid-1990s, continuing to turn in superb supporting performances in films and television.

Harden's road to success was a long one, her work generally being overlooked because the productions were either critically panned or ignored by audiences.

Harden's family frequently moved because of her father's job, living in Japan, Germany, Greece, California, and Maryland.

Harden graduated from Surrattsville High School in Clinton, Maryland in 1976. Continuing to work prolifically in features and television, she earned another Oscar nomination in 2003 for her supporting role in Clint Eastwood's Mystic River (2003), Harden having earlier worked with Eastwood in 2000's Space Cowboys (2000).

Harden's work often makes otherwise mediocre productions worth watching, fully inhabiting any character she portrays.

However, it was just a matter of time before Harden got a chance to truly show her quality on-screen, and that time came in 2000, with Ed Harris's Pollock (2000), in which she played Lee Krasner, artist and long-suffering wife of Jackson Pollock. Harden also worked in the theater and, in 1993, was part of the Broadway cast of Tony Kushner's "Angels in America", playing Harper, the alienated wife of a closeted gay man.

The family relocated often -- she first became interested in the theatre when the family was living in Greece, and she had attended plays in Athens. Harden received a Master of Fine Arts from New York University's Tisch School of the Arts in 1988.